w5: animal models of spinal cord injury
نویسندگان
چکیده
spinal cord injury (sci) leads to a significant health problem associated with a broad range of secondary complications and disabilities. in this regard, animal models can help us to understand the pathobiology of sci and evaluate the effects of potential treatments for sci. in contusion models of sci, different devices including surgical spring-loaded clips, balloons, forceps, weights and the computer-controlled reproducible impact contusion devices were used to create a defined lesion in the spinal cord. to evaluate treatments that target axon regeneration or in case of implantations, transection models may be utilized in which an incision is created into spinal cord. the transection may be complete or incomplete. the unilateral hemisection injury can be a good alternative to complete transection in which structural integrity, function of one side of the spinal cord and bladder and bowel function were preserved. by choosing an appropriate sci method, we can test numerous possibilities for novel therapeutic strategies before clinical investigations.
منابع مشابه
Evaluation of spinal cord injury animal models
Because there is no curative treatment for spinal cord injury, establishing an ideal animal model is important to identify injury mechanisms and develop therapies for individuals suffering from spinal cord injuries. In this article, we systematically review and analyze various kinds of animal models of spinal cord injury and assess their advantages and disadvantages for further studies.
متن کاملAnimal Models of Spinal Cord Injury Pain
J Rehabil Med Suppl 41, 2003 DOI 10.1080/16501960310010197 Patients with spinal cord injury often develop chronic pain syndrome, which is difficult to treat. Several animal models of spinal cord injury have been developed in recent years which have significantly advanced our understandings of pathophysiology of this condition. This paper reviews some recent data in the pharmacological treatment...
متن کاملEndogenous Proliferation after Spinal Cord Injury in Animal Models
Spinal cord injury (SCI) results in motor and sensory deficits, the severity of which depends on the level and extent of the injury. Animal models for SCI research include transection, contusion, and compression mouse models. In this paper we will discuss the endogenous stem cell response to SCI in animal models. All SCI animal models experience a similar peak of cell proliferation three days a...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
مجله علوم اعصاب شفای خاتمجلد ۲، شماره ۴، صفحات ۴۸-۴۸
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023